CBD (cannabidiol) works in dogs by interacting with the endocannabinoid system (ECS), which is present in all mammals, including dogs. The ECS helps regulate various physiological functions like pain, mood, appetite, and inflammation. CBD doesn’t bind directly to the receptors in the ECS the way THC (tetrahydrocannabinol) does, but it can influence them indirectly, leading to a variety of potential benefits for dogs.